Basic Information
VIS ID
TVIS10005866
Fusion event
HBV-chr13 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3008
Orient
+
Integrated sequence
CTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGA| |GGCAAATCAGGTAGGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACA
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
104280510/103628160 (Hg38)
End
104280510/103628160 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/1582156; hsa-mir-1267/Downstream/3903011;
Nearest TSS
ENST00000623511/Upstream/202960; ENST00000640578/Downstream/1837707;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/781747, chr13-CpG: 29/Downstream/2864900
Upstream sequence
gaatattttctcacatgctgtagcttggcagtttattttctttatagcccctttcaaagagcattttaatgaagtcaagtttatcaatattttcttttct
Downstream sequence
tatttatgcttattgtgtcctaacttagaaacaattacttactctaagtgtgcaaaaatattctatttttttttcctaaaagcttaatagtgttagcttt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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