Basic Information
VIS ID
TVIS10005875
Fusion event
HBV-LOC100996442 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2067
Orient
-
Integrated sequence
TCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAG| |GCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTC
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
164190/164190 (Hg38)
End
164190/164190 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC100996442
Nearest miRNA
hsa-mir-1302-2/Upstream/133687; hsa-mir-101-1/Downstream/23701;
Nearest TSS
ENST00000473358/Upstream/3744; ENST00000412666/Downstream/194667;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/28627, chr1-CpG: 104/Downstream/35061
Upstream sequence
attgccctcaagccacggcaatgagaacaaaattcggtaaaaacaaaacaaaacaaaacaaaaTCACCATAAAATAACTCAGACTTAATTAAATACAACC
Downstream sequence
CTAGTGGTGAATGACTAAAGATGGATTACTCATAACAGAGACAACAGTCCAATAAGAATCCAGGAATCTTACCTTTTAATAACAAAAAAATCCTTTCCTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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