Basic Information
VIS ID
TVIS10005876
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1761
Orient
+
Integrated sequence
ACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAA| |AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
End
700042/764662 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-12136/Upstream/131977; hsa-mir-101-1/Downstream/402442;
Nearby gene
RNU6-1199P(-6326) ; LOC100288069(+203) ;
Upstream sequence
ccacggcaatgagaacaaaattcggtaaaaacaaaacaaaacaaaacaaaaTCACCATAAAATAACTCAGACTTAATTAAATACAACCCTAGTGGTGAAT
Downstream sequence
GACTAAAGATGGATTACTCATAACAGAGATAACGGTCCAATAAGAATCCAGGAATCTTACCTTTTAATAACAAAAAAATCCTTTCCTTCTAAAGTAACAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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