Fusion event
HBV-chr1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
ACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAA| |AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT
Nearest miRNA
hsa-mir-12136/Upstream/131977; hsa-mir-101-1/Downstream/402442;
Upstream sequence
ccacggcaatgagaacaaaattcggtaaaaacaaaacaaaacaaaacaaaaTCACCATAAAATAACTCAGACTTAATTAAATACAACCCTAGTGGTGAAT
Downstream sequence
GACTAAAGATGGATTACTCATAACAGAGATAACGGTCCAATAAGAATCCAGGAATCTTACCTTTTAATAACAAAAAAATCCTTTCCTTCTAAAGTAACAT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).