MIR17HG _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005895
Fusion event
HBV-MIR17HG integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2517
Orient
-
Integrated sequence
GCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTA| |ATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAA
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
92006588/91354334 (Hg38)
End
92006588/91354334 (Hg38)
Orient
-
Location type
Exon
Target gene
MIR17HG
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1297/Upstream/2943; hsa-mir-1267/Downstream/1135829;
Nearest TSS
ENST00000623511/Upstream/222927; ENST00000618596/Downstream/44273;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/5147, chr13-CpG: 53/Downstream/44565
Nearest cancer related gene
MIR17HG(OG, No orient, 0)
Upstream sequence
TAGCTTAGTGGTTGTATGAGTTACATCTTATTAAAGTCGAAATTAATGTAGTTTTCTGCCTTGATAACATTTCATATGTGGTATTAGTTTTAAAGGGTCA
Downstream sequence
TTAGGAAAATGCACATATTCCATGAATTTTAAGACCCATAGAAAAGTTGAAGAATGCTTAATTTTCTTATCCAGTAATGTAAACACAGAGACAGAACATT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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