Basic Information
VIS ID
TVIS10005902
Fusion event
HBV-chr15 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
48094890/47802693 (Hg38)
End
48094890/47802693 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/2369564; hsa-mir-11181/Downstream/1366377;
Nearest TSS
ENST00000557528/Upstream/36113; ENST00000558370/Downstream/42263;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/83846, chr15-CpG: 53/Downstream/375117
Nearby gene
LINC01491(+691) ;
Upstream sequence
AAGTCCATGAGGGCAGGGGAGTAATAGTAGAGGGAGCAGTAGGTTGAGAGGAGAGAATTGTTAATAATAATAGTTGTTCTGAATCCAGCTGTTTATGCAT
Downstream sequence
GAATCAGACTTGTGCATGTCTTCTAGTAGTCAATTCTTTCCATCTCTCAGGTGCTCTGTGTTTTTATATTGTTACTATTGTTCATTATCATTATTATGGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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