ADAM10 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005903
Fusion event
HBV-ADAM10 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1815
Orient
+
Integrated sequence
TGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCG
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
58903266/58611067 (Hg38)
End
58903266/58611067 (Hg38)
Orient
-
Location type
Exon
Target gene
ADAM10
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-155-5p ; hsa-mir-484 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-451a ; hsa-mir-103a-3p ; hsa-mir-448 ; hsa-mir-655-3p ; hsa-mir-449a
Nearest miRNA
hsa-mir-10393/Upstream/3238033; hsa-mir-11181/Downstream/560116;
Nearest TSS
ENST00000557528/Upstream/23560; ENST00000559745/Downstream/10437;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/544489, chr15-CpG: 125/Downstream/137815
Upstream sequence
TTTTATACTCTTGTGTTTTTAAAAGCCTTACTTTTCTTCATACAGCATACATGGCATAATTCTTTATCATCTTTGCCATCAGAACTGGCACACGTACACT
Downstream sequence
CCTCTAAGCCATATTTCTCACAGATAGAACCTGCACATTGCTAGAAGAAAAATAAAAGACAAATTGTTTAATCCCTATACAGTCAAACCTATTTTTTATA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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