hsa-mir-548ai _LIHC.png
hsa-mir-497-3p _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005906
Fusion event
HBV-chr18 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2192
Orient
-
Integrated sequence
TTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCA| |GACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGC
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
12701550/12701551 (Hg38)
End
12701550/12701551 (Hg38)
Orient
+
Location type
PSMG2,intron CEP76,intron PSMG2,promoter
Target gene
CEP76 ; PSMG2
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-let-7c-5p ; hsa-mir-570-5p ; hsa-mir-595 ; hsa-mir-1225-5p ; hsa-mir-1229-5p ; hsa-mir-548ag ; hsa-mir-548ai ; hsa-mir-548ba ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-503-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6504-3p ; hsa-mir-497-3p ; hsa-mir-4438 ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-1200 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4264 ; hsa-mir-1281 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-4485-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-622
Nearest miRNA
hsa-mir-3976/Upstream/1046610; hsa-mir-1-2/Downstream/758396;
Nearest TSS
ENST00000575820/Upstream/1184; ENST00000590217/Downstream/875;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/42823, chr18-CpG: 110/Downstream/634
Upstream sequence
AGGgaatcttaccagctttcaacttagtagatgtgtaacctcaagccaacttatttaccctttataaatctgtttcgtcaccgataagaatggaaaaacc
Downstream sequence
tagtgtagtgccctctcacgatagtgttgtgaggattaaagatactagacagcacaaagcctggcacacaagggcaccataaatggtcgctttTATCACT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate