Basic Information
VIS ID
TVIS10005911
Fusion event
HBV-chr22 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
206
Orient
-
Integrated sequence
TCACCCATATCGTCAATCTTCTCGAGGACTGGGGACCCTGCACAGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGG| |GGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCA
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42734538/42338532 (Hg38)
End
42734538/42338532 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/415235; hsa-let-7a-3/Downstream/2862422;
Nearest TSS
ENST00000624155/Upstream/60344; ENST00000428765/Downstream/5084;
Nearest CpG islands
chr22-CpG: 22/Target, None/Upstream, None/Downstream
Upstream sequence
GGGGGCCTCAGCAGAGCCCCGTCCCTCCCGGCAGCCCGGCCTGCAGGGGCCACTCGGCCAATCCCGAAGAGCTCGCTCAGGGGCTGCGAGTGGAAGGGCT
Downstream sequence
GGGAAAATAATTACCGAGGAGGCCCGGGAGGGAGGCGGGGAGGCTGGCGAGAGGCTTAATGAAACTGCTAACGCGTTAGTGATTCCTGCCTGCTCGGGAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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