Basic Information
VIS ID
TVIS10005920
Fusion event
HBV-LOC105374914 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
8984869/8984636 (Hg38)
End
8984869/8984636 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105374914
Nearest miRNA
hsa-mir-3691/Upstream/2815201; hsa-mir-10398/Downstream/1455081;
Nearest TSS
ENST00000381078/Upstream/549025; ENST00000645232/Downstream/177141;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/548728, chr6-CpG: 41/Downstream/414224
Upstream sequence
aaatttcctctaattatattatagatttagaaaatagttaacctctaaatctggtatacttttactgttaggccatagattaaaaaaacaagctatacca
Downstream sequence
tattaagtctgtctccattgggcatctgaattattctggccttcagtttccatattggtaagatgtctatcataatGATTTTATATAAAACAGTGTTAGG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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