Basic Information
VIS ID
TVIS10005923
Fusion event
HBV-LOC105375825 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1922
Orient
-
Integrated sequence
TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG| |AATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGC
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
49706164/48793605 (Hg38)
End
49706164/48793605 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375825
Nearest miRNA
hsa-mir-124-1/Upstream/5897330; hsa-mir-10400/Downstream/12921183;
Nearest TSS
ENST00000518652/Upstream/58294; ENST00000522267/Downstream/127824;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/58176, chr8-CpG: 18/Downstream/41231
Upstream sequence
CCTAACACTATACTGTGAAGAGCTAGGGAAAGAAGGGACGAAAGGCTACTAGGAAATTACATGTAAGCATTAGTTTAATTAGATTCTATCCCTATCCTGG
Downstream sequence
tgacattaatataacccactgttcttcagatttgcctagttttacttattcttatttgtgtgtgtgtgcatgcaagtatttagccctgggcaattctatc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate