Fusion event
HBV-chr8 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
ATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCC| |TTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTA
End
82361761/81449526 (Hg38)
Nearest miRNA
hsa-mir-12123/Upstream/1208053; hsa-mir-10400/Downstream/9755959;
Upstream sequence
gtgaatctaaacatatctaaacatagaggttgggcgaggtggctcacgcctgtaatcccagcactttgggaggccaatgcaggcagatcacttgaggtca
Downstream sequence
CCAGACAAGTTTGGACCGTGATGGGATTCTGAGGCCAATATATGGGCCAAAGGCACAGATCAAAGCAATGAGGGAAGACCCGGACTGAACTAGGCCTGAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).