Fusion event
HBV-chr1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
End
105273991/104731369 (Hg38)
Nearest miRNA
hsa-mir-101-1/Upstream/4450061; hsa-mir-11399/Downstream/3165854;
Upstream sequence
ggaaggacttctagtactatgttgaattagaatggtgatagtggacatctttttcttgttccagttcttattagaaaggctttcattatttacctattca
Downstream sequence
gtacaatgttagttgaggttttgtcatatatggcttttattattttgaaatctgtttcttctacatctagttttttgagaatttttatcatgtatgggtg
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).