AKR1C3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005944
Fusion event
HBV-AKR1C3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1732
Orient
+
Integrated sequence
AGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTG| |GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
5115733/5073541 (Hg38)
End
5115733/5073541 (Hg38)
Orient
-
Location type
Intronic
Target gene
AKR1C3
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-5699/Upstream/1082282; hsa-mir-107/Downstream/1078655;
Nearest TSS
ENST00000439456/Upstream/24729; ENST00000603312/Downstream/4097;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/246936, chr10-CpG: 54/Downstream/338927
Upstream sequence
acctttggtaacataatggaagacatagaacaaccctcccctacacagactcctcagtgggacagcccaattacatccactgtcctgagcacatggaccc
Downstream sequence
cctttctctctcagtcttacccacatgactcagcgagcagctccagcccagatcacagaaccatatgaagaattgaaaaccccaccttctcaagagggcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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