hsa-mir-130b-3p _LIHC.png
PDE3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005949
Fusion event
HBV-PDE3B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2495
Orient
-
Integrated sequence
CGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTAT| |TCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGG
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
14749561/14728015 (Hg38)
End
14749561/14728015 (Hg38)
Orient
-
Location type
Intron
Target gene
PDE3B
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-124-3p ; hsa-mir-93-5p ; hsa-mir-16-5p ; hsa-mir-562 ; hsa-mir-3119 ; hsa-mir-4735-5p ; hsa-mir-5683
Nearest miRNA
hsa-mir-210/Upstream/2564248; hsa-let-7a-2/Downstream/1241518;
Nearest TSS
ENST00000527297/Upstream/29176; ENST00000525439/Downstream/60924;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/82887, chr11-CpG: 68/Downstream/163339
Upstream sequence
ATATACTCTTGGTTTTATGACATTCCATTTTGACAGTGATGAAGAGCATGCTTATAGGCATCGTTGAAAAGGAATGTTAGAACTGTTTATGTGATAGTTC
Downstream sequence
TACAAGTTTCTTACATTTATCTATTATAGAAAGATCTATCATACATGCTTACTTTTCACAGAGTTTATAATATATGCATATGTTTTAATGGTTTGTTATA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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