Fusion event
HBV-chr14 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCT| |ATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTC
End
41786429/41317226 (Hg38)
Nearest miRNA
hsa-mir-208a/Upstream/4364835; hsa-mir-1185-1/Downstream/6443769;
Upstream sequence
CATAATAATAAGGGATAATTGTTTTTTATGCTAAATTTTACTGTTTTATATCTTGGAGATTACTAATTTTTGAAACTTAAAATACCTAAAATTTAATTAT
Downstream sequence
GATTAACATTTCATAAGCCGTGGACCTGATTGAAAGTGATCTCTTGACTGTTTCATGGAATGACTAAATATTGTATTCCCTGACTGACAAGTTTTGTAAT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).