Basic Information
VIS ID
TVIS10005961
Fusion event
HBV-SNHG14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
-
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25431870/25186723 (Hg38)
End
25431870/25186723 (Hg38)
Orient
+
Location type
Promoter
Target gene
SNHG14
Nearest miRNA
hsa-mir-1268a/Upstream/1624592; hsa-mir-10393/Downstream/662024;
Nearest TSS
ENST00000557528/Upstream/99062; ENST00000557558/Downstream/159308;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/230816, chr15-CpG: 143/Downstream/251525
Upstream sequence
ATCACCCCTTCCTTATGAGGGAGTGGTGGGAAGGGTATCCTCCTGAGGTAGGAAGGCCCGCTGTGGAAGGAACTTTCCTGGAAATTTGCAGTCCAGACTG
Downstream sequence
CTTCTGAGCCATGAGGTCATCTCCGGGGTGGCGGGGTCTTGGGCCCAAGGAAAGGAGAAGACACCATATGTCTCCCGATTGGTTGAGTATGGCTCCACTC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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