hsa-mir-3143 _LIHC.png
hsa-mir-6798-3p _LIHC.png
hsa-mir-4434 _LIHC.png
hsa-mir-499a-3p _LIHC.png
MAF _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005964
Fusion event
HBV-MAF integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1923
Orient
-
Integrated sequence
TTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA| |ATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCC
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
79562057/79528160 (Hg38)
End
79562057/79528160 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
MAF
miRNAs that regulate target gene
hsa-mir-621 ; hsa-mir-302c-5p ; hsa-mir-6798-3p ; hsa-mir-3143 ; hsa-mir-4640-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-618 ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-10b-3p ; hsa-mir-205-3p ; hsa-mir-6514-5p ; hsa-mir-4802-5p ; hsa-mir-451b ; hsa-mir-486-3p ; hsa-mir-212-5p ; hsa-mir-147a ; hsa-mir-210-3p ; hsa-mir-3151-5p ; hsa-mir-342-5p ; hsa-mir-3621 ; hsa-mir-3650 ; hsa-mir-3656 ; hsa-mir-3911 ; hsa-mir-4447 ; hsa-mir-4455 ; hsa-mir-4472 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-491-5p ; hsa-mir-574-5p ; hsa-mir-608 ; hsa-mir-644a ; hsa-mir-6737-5p ; hsa-mir-6742-5p ; hsa-mir-6747-5p ; hsa-mir-6796-5p ; hsa-mir-6812-5p ; hsa-mir-6819-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-mir-1225/Upstream/2659141; hsa-mir-11401/Downstream/1856858;
Nearest TSS
ENST00000527434/Upstream/22557; ENST00000617603/Downstream/71742;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1427991, chr16-CpG: 44/Downstream/61434
Nearest cancer related gene
MAF(OG, No orient, 0)
Junction sequence
GGCAAAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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