Basic Information
VIS ID
TVIS10005970
Fusion event
HBV-chr19 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1813
Orient
+
Integrated sequence
ACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACC
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11351118/11240442 (Hg38)
End
11351118/11240442 (Hg38)
Orient
+
Location type
LOC55908,intron DOCK6,intron
Fragile sites / regions
FRA19B
Target gene
ANGPTL8 ; DOCK6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-361-5p ; hsa-mir-142-3p
Nearest miRNA
hsa-mir-1181/Upstream/126908; hsa-let-7e/Downstream/255102;
Nearest TSS
ENST00000633603/Upstream/545; ENST00000621731/Downstream/13225;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/31365, chr19-CpG: 34/Downstream/2842
Upstream sequence
CCAGAACTCGCTTCTGCACCTTGAGTCCCAAagacctcccagatcagcctcccagctctgtggcctctaccctgcatgtccccagacaaaactcaagtcc
Downstream sequence
ttttgtgtgcctcagtttcccttttgtgtgcctcagttgcaaataagggcaacacctgatatctcacagtagggccaggtactcaatgcaggtaaaatat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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