DIS3L2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005981
Fusion event
HBV-DIS3L2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1759
Orient
+
Integrated sequence
GGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTT| |AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTA
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
233169738/232305028 (Hg38)
End
233169738/232305028 (Hg38)
Orient
-
Location type
Intron
Target gene
DIS3L2
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10b/Upstream/132281; hsa-mir-149/Downstream/245446;
Nearest TSS
ENST00000437798/Upstream/55688; ENST00000417808/Downstream/23480;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/342902, chr2-CpG: 174/Downstream/45942
Upstream sequence
tctttcctctcttttttctatttctgtatctgttaatgctgcattgtaggcaacttcctcaaaagtgtctgtcactttattctccttgtagcagtttact
Downstream sequence
atcggctgcttaataacccttcccaatatgaatatttggtttttattttattttatttattttttgagatggagtctcgctctgtcacccaggctggagt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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