Basic Information
VIS ID
TVIS10005983
Fusion event
HBV-chr2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1816
Orient
+
Integrated sequence
GTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGT
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh37/hg19
Start
238216130/237307487 (Hg38)
End
238216130/237307487 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2J
Nearest miRNA
hsa-mir-10b/Upstream/4756914; hsa-mir-149/Downstream/203444;
Nearest TSS
ENST00000437798/Upstream/50396; ENST00000429898/Downstream/22693;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/221254, chr2-CpG: 22/Downstream/64345
Nearby gene
LOC105373954(-9566) ; LOC110121230(+5690) ;
Upstream sequence
ATGGAATAAAGCCAAAAAGAACTGAAAGGCAGGGATACAATAAGATGACAATTTTGATTCCAGTTCCTACTTGACAAAGACTAAAAGCACCCTCTGAATG
Downstream sequence
GTTGCAATGGCCCCTGTGACTTCCTGTGTAGTAGGAGACCGGGCGACATCAAGTTGGCATTAAATCACACACTTGGCTTCTGGCCTTGCTCAAGCTAGGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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