Basic Information
VIS ID
TVIS10005990
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1809
Orient
+
Integrated sequence
AAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATT
Host Sequence
Chromosome
chr3
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
99794725/100075881 (Hg38)
End
99794725/100075881 (Hg38)
Orient
-
Location type
FILIP1L,intron C3orf26,intron
Target gene
CMSS1 ; FILIP1L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-3163 ; hsa-mir-100-3p ; hsa-mir-4282 ; hsa-mir-548e-5p ; hsa-mir-1200 ; hsa-mir-2355-5p ; hsa-mir-6778-3p ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-4649-3p ; hsa-mir-486-5p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-5196-3p ; hsa-mir-4290 ; hsa-mir-4758-3p ; hsa-mir-4323 ; hsa-mir-4687-5p
Nearest miRNA
hsa-let-7g/Upstream/111483; hsa-mir-12124/Downstream/3448152;
Nearest TSS
ENST00000440867/Upstream/199678; ENST00000479555/Downstream/38383;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/199424, chr3-CpG: 22/Downstream/149379
Junction sequence
TACCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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