Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005992
Fusion event
HBV-MGLL integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2310
Orient
+
Integrated sequence
ACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGC| |CCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCG
Host Sequence
Chromosome
chr3
Cytoband
q21.3
Reference genome
End
127541764/127822921 (Hg38)
Orient
-
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-30c-5p ; hsa-mir-142-3p ; hsa-mir-93-5p ; hsa-mir-205-5p ; hsa-mir-7151-5p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4786-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-6728-3p ; hsa-mir-3200-5p ; hsa-mir-7855-5p ; hsa-mir-4766-3p ; hsa-mir-4733-5p ; hsa-mir-3908 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-624-3p
Nearest miRNA
hsa-let-7g/Upstream/235745; hsa-mir-12124/Downstream/1023887;
Nearest CpG islands
chr3-CpG: 89/Target, None/Upstream, None/Downstream
Upstream sequence
tcttagagatattaaaattctagagtcaatttatcatttaagatctgcttaccaattgtttcccaaagaagtggccataaaaccctccatttcccaacag
Downstream sequence
cacgcgcgcacactcggacacgcgcgcacacacaccgtgcacacacacacacgcacacaTGGGTAGCGGGAGCCCACGCCGGGCGTGTCCGGGACCCCAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).