Fusion event
HBV-chr3 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGC
End
170704275/170986486 (Hg38)
Nearest miRNA
hsa-let-7g/Upstream/563324; hsa-mir-1224/Downstream/120178;
Upstream sequence
aataaatgtcttatcaagtaaatggttagctgtgagtttatgtttaataattgaaaattatgtcattATAAATAATTTTAATGGTACACATAACCAGTTA
Downstream sequence
tctacttttgcactcaattatcaatatgtccagacataggattctagattgaaaatggtttttcttcagaatttcttcagaaggcatttctcctcagctt
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).