Basic Information
VIS ID
TVIS10005998
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1846
Orient
-
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCA| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTAC
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
End
34898026/34896404 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-12113/Upstream/6076736; hsa-mir-1243/Downstream/1529962;
Nearby gene
LOC107986272(+6206) ;
Upstream sequence
GAATTCATTTCCAGTATCATTTCTGCCAAGTTGGCAATTTTCCATACAAATAATTAAAATCTCAGAATTCAACTCATTATATTTTAGAAGGCTTTTCTAA
Downstream sequence
ccccatccatccccctggtgaccaacattctactccctacttatagaagttgactttttaaagttccacatataattgagaccatgtggtatttgtcttt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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