Fusion event
HBV-chr4 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCA| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTAC
End
34898026/34896404 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/6076736; hsa-mir-1243/Downstream/1529962;
Upstream sequence
GAATTCATTTCCAGTATCATTTCTGCCAAGTTGGCAATTTTCCATACAAATAATTAAAATCTCAGAATTCAACTCATTATATTTTAGAAGGCTTTTCTAA
Downstream sequence
ccccatccatccccctggtgaccaacattctactccctacttatagaagttgactttttaaagttccacatataattgagaccatgtggtatttgtcttt
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).