Fusion event
HBV-chr4 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
End
180667297/179746144 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/5322280; hsa-mir-1305/Downstream/2423149;
Upstream sequence
TGATTTAGGCTGGGAAGCCGTTAACTAACCATTCATCATAAAAGGGAGGAAGCAAGAGGACCCACTTGAGTAGGCTGGGACAAATTGCTGTGGTTCAGTT
Downstream sequence
GAGTACTGTGGTTTAAGATGTACGCTTAATCAGAGATCACTTTGTGCTGGTCCGAAAGACTGGGCAGAAAAATATTTTGCTTTATATTACCCAAGTGTAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).