Basic Information
VIS ID
TVIS10006011
Fusion event
HBV-chr6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1821
Orient
-
Integrated sequence
TTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA
Host Sequence
Chromosome
chr6
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
155035623/154714489 (Hg38)
End
155035623/154714489 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/3611713; hsa-mir-1202/Downstream/138871;
Nearest TSS
ENST00000381078/Upstream/203830; ENST00000464628/Downstream/18836;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/203622, chr6-CpG: 139/Downstream/18563
Nearby gene
LOC646274(-4444) ;
Upstream sequence
aggtcaggagattgagaccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaaattaattagccggacatggtggcgcctgtagtcc
Downstream sequence
tggtatcttcagaaagtaatgaggattaggtaaggtcatcagggtgagggccccatgatgcaactgatggctttataagaagaggaagcaatggccagcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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