BTAF1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006022
Fusion event
HBV-BTAF1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2619
Orient
+
Integrated sequence
CCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAA| |GGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGT
Host Sequence
Chromosome
chr10
Cytoband
q23.32
Reference genome
GRCh37/hg19
Start
93786860/92027103 (Hg38)
End
93786860/92027103 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA10D
Target gene
BTAF1
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-15b-5p ; hsa-mir-183-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-107/Upstream/2434276; hsa-mir-1287/Downstream/4037212;
Nearest TSS
ENST00000439456/Upstream/46583; ENST00000462465/Downstream/216143;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/103021, chr10-CpG: 33/Downstream/18652
Upstream sequence
CAGACAAAATAAAAATCCAACCCTAATTAGGTAGTATAAAATAGTACAAGTCTACAAGCCCTCTGACTCGTTGGAACCTCAAAGCATAATATGTGTTACG
Downstream sequence
GTTGCTTAACTGTTTTTCTTATCCAGAAACGTGTGGTTAACGTATACCGATTGATAACCAGAGGAACATTGGAAGAAAAAATAATGGGGTTGCAGAAATT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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