Basic Information
VIS ID
TVIS10006027
Fusion event
HBV-LOC105378017 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
-
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
137634215/137313078 (Hg38)
End
137634215/137313078 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378017
Nearest miRNA
hsa-mir-10398/Upstream/2073822; hsa-mir-1202/Downstream/1122135;
Nearest TSS
ENST00000381078/Upstream/93629; ENST00000642830/Downstream/181172;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/93537, chr6-CpG: 72/Downstream/175127
Upstream sequence
AGATTTTTTTCATTCCTGGTTTCTGTTATCCACTATGCCTTGACCTTCGCTCTGTCCATATGATCAAATTACTTCCTGAACCTAGACCGTTGGGCGCGTC
Downstream sequence
cactgtgcccagcctcttttgttaatcttcattttgttatagggcctcagccatgaacctaggataagtagaaggaaagaaatatttttcctcccttcca
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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