Basic Information
VIS ID
TVIS10006030
Fusion event
HBV-LINC02645 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2620
Orient
-
Integrated sequence
CTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAG| |GAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTATCCTGAACATGCAGTT
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
2490394/2448200 (Hg38)
End
2490394/2448200 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02645
Nearest miRNA
hsa-mir-5699/Upstream/372111; hsa-mir-107/Downstream/1542960;
Nearest TSS
ENST00000439456/Upstream/848; ENST00000431209/Downstream/51521;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/132923, chr10-CpG: 68/Downstream/53071
Upstream sequence
GCCATTCTGTGCTTTCAGATTTTTTTAATGTGtatttttaataaaatgatatttataattCAGAACTCAGGTCATTGTGACCCTTTTCTTGCAATCTAAA
Downstream sequence
ATAAGATCTATAATTTTGTTTTGGAAGCATGTAGATAAGGCATTAGAAGTAAGGCATTTGTTGTACTGAAACCAAACTCCTAAAAGACACATTCCAGAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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