Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006033
Fusion event
HBV-ASPH integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1825
Orient
-
Integrated sequence
AGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAAT
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
Start
End
62415375/61502816 (Hg38)
Orient
-
Location type
Exon
Target gene
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-16-5p ; hsa-mir-921 ; hsa-mir-1-3p ; hsa-mir-1225-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-4722-5p ; hsa-mir-6081 ; hsa-mir-7854-3p ; hsa-mir-8069 ; hsa-mir-4699-5p ; hsa-mir-4459 ; hsa-mir-6165 ; hsa-mir-4506 ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-6734-5p ; hsa-mir-4728-5p ; hsa-mir-6073 ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-423-5p ; hsa-mir-1914-3p ; hsa-mir-3184-5p ; hsa-mir-3174 ; hsa-mir-6755-5p
Nearest miRNA
hsa-mir-124-1/Upstream/18606541; hsa-mir-10400/Downstream/211972;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/362944, chr8-CpG: 102/Downstream/211181
Upstream sequence
TGCGCCCGCCACTCACCCTGTATGCACCGGGCTGGCCACCGGGCTGATGTTGTCTGAGGTCTCGGTGGCCGGGCTGCTGGGGATGAGGGAGTCCTCATCA
Downstream sequence
TATCTTTTACTAAGAAGAATTAAAAGAGGGAAGTCTGAGTTCCCCAGTAATGCTACCATTAAATAGCTAGAAGTAAAGCATTTATACAGCTTGTCATTAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).