Basic Information
VIS ID
TVIS10006035
Fusion event
HBV-chr16 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2886
Orient
-
Integrated sequence
GAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGG| |ACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACC
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46405063/46390716 (Hg38)
End
46405063/46390716 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12227043; hsa-mir-11401/Downstream/3901900;
Nearest TSS
ENST00000527434/Upstream/10603829; ENST00000569239/Downstream/193537;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10288003, chr16-CpG: 124/Downstream/36742
Upstream sequence
gattccgtttgatgattccattctattctattcgatgatgattccattcgattccatttgatgatgattggattcgattccatttgatgatttcatttga
Downstream sequence
ttccattcgttaatgatttcgatcaattccattcgatgattccattcgattccattcgataatgattacatccgagtccattcgatgattccatttgagc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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