PRKAR1B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006041
Fusion event
HBV-PRKAR1B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1837
Orient
-
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTA| |ATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTG
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
729320/689683 (Hg38)
End
729320/689683 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA7B
Target gene
PRKAR1B
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-mir-10399/Downstream/333250;
Nearest TSS
ENST00000635602/Upstream/86498; ENST00000438961/Downstream/2111;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/18690, chr7-CpG: 33/Downstream/21468
Junction sequence
CAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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