VISDB Viral Integration Site DataBase

VIS ID

TVIS10006045

Fusion event

HBV-REXO1 integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

1815

Orient

+

Integrated sequence

TGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCG

Chromosome

chr19

Cytoband

p13.3

Reference genome

Start

End

1840632/1840633 (Hg38)

Orient

+

Location type

Intron

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-484 ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-6810-5p ; hsa-mir-491-5p ; hsa-mir-92a-2-5p ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-4664-5p ; hsa-mir-4652-5p ; hsa-mir-342-5p ; hsa-mir-3191-3p ; hsa-mir-3144-5p ; hsa-mir-25-5p ; hsa-mir-6820-5p ; hsa-mir-658 ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-6081 ; hsa-mir-4707-3p ; hsa-mir-2467-3p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-7114-3p ; hsa-mir-4468 ; hsa-mir-1180-5p ; hsa-mir-551b-3p ; hsa-mir-551a ; hsa-mir-7108-3p ; hsa-mir-662 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-195-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-1203 ; hsa-mir-1251-5p ; hsa-mir-1301-5p ; hsa-mir-1909-3p ; hsa-mir-3151-5p ; hsa-mir-3165 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-3190-3p ; hsa-mir-3196 ; hsa-mir-328-5p ; hsa-mir-3656 ; hsa-mir-4283 ; hsa-mir-4285 ; hsa-mir-4446-3p ; hsa-mir-4467 ; hsa-mir-4492 ; hsa-mir-4498 ; hsa-mir-4505 ; hsa-mir-4508 ; hsa-mir-4651 ; hsa-mir-4669 ; hsa-mir-4721 ; hsa-mir-4722-5p ; hsa-mir-4731-5p ; hsa-mir-4768-3p ; hsa-mir-4781-5p ; hsa-mir-486-3p ; hsa-mir-5001-5p ; hsa-mir-504-3p ; hsa-mir-5787 ; hsa-mir-6079 ; hsa-mir-6087 ; hsa-mir-608 ; hsa-mir-6132 ; hsa-mir-637 ; hsa-mir-6502-5p ; hsa-mir-671-5p ; hsa-mir-6722-3p ; hsa-mir-6733-3p ; hsa-mir-6795-5p ; hsa-mir-6804-5p ; hsa-mir-6816-3p ; hsa-mir-6816-5p ; hsa-mir-6822-3p ; hsa-mir-6828-5p ; hsa-mir-6836-5p ; hsa-mir-6847-5p ; hsa-mir-6880-5p ; hsa-mir-6885-5p ; hsa-mir-6887-5p ; hsa-mir-7109-5p ; hsa-mir-7154-3p ; hsa-mir-7-5p ; hsa-mir-762 ; hsa-mir-8071 ; hsa-mir-92b-5p

Nearest miRNA

hsa-mir-1302-11/Upstream/24395; hsa-let-7e/Downstream/393429;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/12086, chr19-CpG: 20/Downstream/7057

Upstream sequence

TCCCCAGAGCCCACAGCCCTAATCCCACTTCCAGCCACAGGCAAACTCCTATTCATCCTCCAAAACCCAGCCCAGTAATCCTGTGTTTGGAAACACTCGC

Downstream sequence

CCCACCCCCCTGCAACTCTGAGTGACACCCGGGCCCGCCCCACGTCACCCCTCCACTCCCTGCAACTCCAAGTGACAGCTGCCCTGTCTCCTGGACCCGG