Basic Information
VIS ID
TVIS10006050
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3033
Orient
-
Integrated sequence
GTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCA| |TTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTGCCT
Host Sequence
Chromosome
chr5
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
19301235/19301126 (Hg38)
End
19301235/19301126 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/2145134; hsa-mir-103a-1/Downstream/12634976;
Nearest TSS
ENST00000502646/Upstream/158780; ENST00000513573/Downstream/177510;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1645512, chr5-CpG: 45/Downstream/1004327
Upstream sequence
cagggttagggtcagggtcagggtcagggtacagcacttccgggtcagggtcagggtcagggtcagggtcagggttagggtcagggtcagggtcagggtA
Downstream sequence
GCATAAGATTCCCAGAGGTGCTTGTGACCCAGCTATGACCCAGCCTTCCGATTCTACTTTGAGGAATCCACAAACTAAGTTGGTTtatatatttatctat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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