Basic Information
VIS ID
TVIS10006059
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3181
Orient
+
Integrated sequence
CCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTC| |TAAGAGACAGTCATCCTCAGGCCATGCAGTGGAA
Host Sequence
Chromosome
chr1
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
168519801/168550563 (Hg38)
End
168519801/168550563 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/174942; hsa-mir-1182/Downstream/1600815;
Nearest TSS
ENST00000473358/Upstream/6566; ENST00000367818/Downstream/25910;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/323962, chr1-CpG: 153/Downstream/554965
Nearby gene
RPL7AP19(-6566) ;
Upstream sequence
cactcataggtgggaattgaacaatgagaacacttggacacagggtgcggaacatcacacaccagggcctgtcgtgtggtgggggtaggagggagggata
Downstream sequence
gcattagtagatatacctaatataaatgacaagttaatgggtgcagcacaccaacatggcacgtgtatacatatataacaaacctgcacattgtgcacat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate