Basic Information
VIS ID
TVIS10006063
Fusion event
HBV-MICU1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1804
Orient
+
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
74239643/72479885 (Hg38)
End
74239643/72479885 (Hg38)
Orient
+
Location type
MIR1256,intron CBARA1,intron
Target gene
MICU1
miRNAs that regulate target gene
hsa-mir-877-5p
Nearest miRNA
hsa-mir-1265/Upstream/689085; hsa-mir-107/Downstream/241144;
Nearest TSS
ENST00000439456/Upstream/124655; ENST00000431638/Downstream/21861;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/124851, chr10-CpG: 42/Downstream/145824
Upstream sequence
caaggtgctaggattataggtgtgagccacagcacccggcTGGTTTGTCATGTTTTTTAAACTTCTGATTATAAATCTCTTCAGGTGGAAATGTTCTCTC
Downstream sequence
TTATTCTtccttattttgtcacacttggcccacttcactcctatatgttatttgcctaattcctgtagatacttgagaatgtaacAATGGCAGAaaatat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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