Fusion event
HBV-chr22 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCT| |CGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGG
End
50152806/49759158 (Hg38)
Nearest miRNA
hsa-let-7a-3/Upstream/215692; hsa-mir-12114/Downstream/203708;
Upstream sequence
caagcatttaaataagaaacgctaatccttcaaacattttttcaacataacggaagagaaggtaagacttcTAgatatggtttggatgtcttgtcccctc
Downstream sequence
caaatctcatgttgaaatgagatctccaatgctggaggtaggcctagtgggaggcatttgggtcacagggctggatgcctcaagaatggcttgcagaaat
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).