Basic Information
VIS ID
TVIS10006089
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1982
Orient
-
Integrated sequence
CTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTC| |GAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTG
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
End
132299939/132964247 (Hg38)
Orient
-
Location type
Promoter
Fragile sites / regions
Nearest miRNA
hsa-mir-10397/Upstream/598648; hsa-mir-103a-1/Downstream/463349;
Nearest CpG islands
Nearby gene
AFF4(-585) ;
Upstream sequence
CAGGTATTTTAATCTTACATGGATGAGCATGGGAATGTCGGAATAAGGAATGCCTTAAAACTATTTTCTGAATGTATATTTTATTTCCTTTGAAAATGGT
Downstream sequence
tgttgtcgcccaggctggagtacaatggcgggatctcggctcactgcaacctccgcctcccgagttcaagcgattctagtacctcagcctccggagtagc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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