Fusion event
HBV-chr5 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTC| |GAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTG
End
132299939/132964247 (Hg38)
Nearest miRNA
hsa-mir-10397/Upstream/598648; hsa-mir-103a-1/Downstream/463349;
Upstream sequence
CAGGTATTTTAATCTTACATGGATGAGCATGGGAATGTCGGAATAAGGAATGCCTTAAAACTATTTTCTGAATGTATATTTTATTTCCTTTGAAAATGGT
Downstream sequence
tgttgtcgcccaggctggagtacaatggcgggatctcggctcactgcaacctccgcctcccgagttcaagcgattctagtacctcagcctccggagtagc
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).