Basic Information
VIS ID
TVIS10006106
Fusion event
HBV-NBPF20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1789
Orient
+
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
144173629/145372153 (Hg38)
End
144173629/145372153 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
NBPF20
Nearest miRNA
hsa-mir-101-1/Upstream/28277425; hsa-mir-1182/Downstream/478434;
Nearest TSS
ENST00000473358/Upstream/84398; ENST00000524525/Downstream/31150;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/84410, chr1-CpG: 95/Downstream/52810
Upstream sequence
GCAGATGTAAAAAATTCACAGAACTATGATTTGGACTGAAGGGTTTGTAGATTTCTTCCTTCATTCTAATTTCAGTGTCTAAAATTCTTGCATCCATGAA
Downstream sequence
CGAGCTGGGCATTTGATGAGACAGGGCTGAATACTGCAGTTTTCCTCCTAGAAATCATCTGGGGCATTTTCTTTGAACTGATGGGAACAATAAGGCATAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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