Basic Information
VIS ID
TVIS10006108
Fusion event
HBV-LOC105376360 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
568
Orient
-
Integrated sequence
CGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCCTCTTGTTGC| |TGTACAAAACCTTCGGACGGAAACTGCACTTGTATTCCCATCCCATCATCCTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCCGTTTCTCCT
Host Sequence
Chromosome
chr10
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
3365697/3323505 (Hg38)
End
3365697/3323505 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105376360
Nearest miRNA
hsa-mir-5699/Upstream/1247416; hsa-mir-107/Downstream/667655;
Nearest TSS
ENST00000439456/Upstream/57502; ENST00000421629/Downstream/179333;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/4749, chr10-CpG: 19/Downstream/8422
Upstream sequence
ttgaacccaggaggcggagcttgtagtgagccaagatcgcgccactgcactccagcctgggtgacagagcaagactgtctcaaaaaaaaaaaaaaaaaag
Downstream sequence
aggaaaaTGAAGAAAGGAGAATCCAGGCAAATATCTGAAAGACTCATAATTTTTTTACACtgtccttcccaaatccatgcccacctgggacctcggagtg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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