Basic Information
VIS ID
TVIS10006110
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1916
Orient
-
Integrated sequence
CAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGT| |ATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCG
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64570858/64803386 (Hg38)
End
64570858/64803386 (Hg38)
Orient
+
Location type
Promoter
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-1237/Upstream/434683; hsa-let-7a-2/Downstream/75137;
Nearest TSS
ENST00000527297/Upstream/145; ENST00000413292/Downstream/2606;
Nearest CpG islands
chr11-CpG: 61/Target, None/Upstream, None/Downstream
Nearby gene
MAP4K2(-132) ; MEN1(+128) ;
Nearest cancer related gene
MEN1(TSG, +128) ;
Upstream sequence
ggATGCCCCACCGCCAGTCCGGGAGGAGGCGCCCGCGGGACGGGCCCTCGGCGGCGCGGGGAAGCCCCAAGGCCGGGGCGGAGCCTACGTCCTTCCGCCG
Downstream sequence
CCACTGTCGCTCGCGCTCCACAGGTAGGGAGCGCAAAGTCCCGGGAGCCAGAAGACAGAGGGAAGAGGGGGCGCTCCACTCCCCGCCCCATCCCCAATTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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