ME3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006111
Fusion event
HBV-ME3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1727
Orient
+
Integrated sequence
CCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAG| |GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
86154998/86443956 (Hg38)
End
86154998/86443956 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA11F
Target gene
ME3
miRNAs that regulate target gene
hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10392/Upstream/165558; hsa-let-7a-2/Downstream/1732546;
Nearest TSS
ENST00000527297/Upstream/12366; ENST00000526206/Downstream/54168;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/12402, chr11-CpG: 82/Downstream/227697
Upstream sequence
TCTCCTAATTTCAGACCTTTATATGGCTCCTTCAAACTCCTTCCCATGGTGTCCATACAAGGCACTTCATCACTGGGCCCTCCTTTCCTCTTCAGCCTca
Downstream sequence
cttttagtgtctagactctgtgctaggtgctgaggagccatataaggaaggattctatggtggagaagccatagtcttttctcttatggagactggtgtc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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