Basic Information
VIS ID
TVIS10006115
Fusion event
HBV-SLCO1B7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1652
Orient
-
Integrated sequence
CTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTA| |CATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGA
Host Sequence
Chromosome
chr12
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
21174186/21021252 (Hg38)
End
21174186/21021252 (Hg38)
Orient
-
Location type
Intron
Target gene
SLCO1B7
Nearest miRNA
hsa-mir-1244-3/Upstream/3347858; hsa-let-7i/Downstream/3191169;
Nearest TSS
ENST00000382841/Upstream/5556; ENST00000541784/Downstream/25927;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/468182, chr12-CpG: 34/Downstream/416283
Upstream sequence
AAAACAGGTGAAACAGGATATTTTACATCTTGACCAGAATATAAGCACTCCTAGGATTATAGAAAAGTGATAACCCACTTTATCCATGGTGTGTTGAATT
Downstream sequence
ATCTGTCTTAGTAGATGCTCCCATTCCCGCCCCACCCCCACCCCCTCTTATCACCTCCTCTTCTGACATACATCCTGGGAAATTGACAAAGAGAAGTCCG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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