Basic Information
VIS ID
TVIS10006116
Fusion event
HBV-LOC105369876 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1681
Orient
+
Integrated sequence
CACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAAT| |GTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGC
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
85946537/85552759 (Hg38)
End
85946537/85552759 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC105369876
Nearest miRNA
hsa-let-7i/Upstream/4394298; hsa-mir-1178/Downstream/1192309;
Nearest TSS
ENST00000382841/Upstream/234699; ENST00000551529/Downstream/283811;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/271837, chr12-CpG: 52/Downstream/2482569
Upstream sequence
ctggaatgtgattccataatttgcatttccaagaagttaccaggcaatgttgatgctgatctgggaaccaTTCATCCTAGGATGAATCCTATAAGCAATT
Downstream sequence
AACAAACAGGACAAATGTTTTAGTCTCTTTGTATCTCTGGAATGAAATTGACGGCAAGAATATATAGTGGCTTACATTTTGTCAATCATCTTTTCTTAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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