Basic Information
VIS ID
TVIS10006135
Fusion event
HBV-LOC105373779 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1927
Orient
+
Integrated sequence
CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT| |GGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAG
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
185327616/184462889 (Hg38)
End
185327616/184462889 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105373779
Nearest miRNA
hsa-mir-10b/Upstream/83845; hsa-mir-1244-1/Downstream/3834603;
Nearest TSS
ENST00000437798/Upstream/558360; ENST00000613975/Downstream/135477;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1202034, chr2-CpG: 72/Downstream/135230
Upstream sequence
TCACAAGGACACAAAAATAGAAACAGAATTATTATGAATTTATTTCAGGACATTAATGTATTTCCATCTTTCTTTGCATTTATAAAATGTCAAGTATTTT
Downstream sequence
CAAATAGTTTGCCTACTATTAGGGATCTAATACGTATTTGTCTTGATATAGTGGATGAACGTCTATATTCTCTGTCTCTTCAATAGCCTAAAATTAGTGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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