FN1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006140
Fusion event
HBV-FN1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
-
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
216280173/215415450 (Hg38)
End
216280173/215415450 (Hg38)
Orient
-
Location type
Intron
Target gene
FN1
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-10b/Upstream/1657291; hsa-mir-1244-1/Downstream/2485063;
Nearest TSS
ENST00000437798/Upstream/5500; ENST00000412951/Downstream/5820;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/103041, chr2-CpG: 43/Downstream/20094
Upstream sequence
AGCAAATTCTAATTTTGGAAGGTTTTCATCAAGAATGAATCTACTACCTAAGAAGGAAACAACATTCCAAAGGCCATATGAGATGATGTAAAACAAACAC
Downstream sequence
ATTTCTAAATGGGGGTAGAATCTTAGACAAATAGCAAAGGTAATAATTAAAGACCTAGTTTTATTTCTCATCAGTCTAAGCAGTCTATCAGTTTGGAAAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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