Fusion event
HBV-chr8 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAA| |TGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGG
End
135835512/134823269 (Hg38)
Nearest miRNA
hsa-mir-1204/Upstream/18324; hsa-mir-10400/Downstream/5909295;
Upstream sequence
GGCAATGGTAGGAAGCATCAGTAGAAATGTTATTCATTAAAGACAGTTCAAATAAAAATGAATGTTACTTTTAAGGAACTTATCTTTTACTAAGCATACT
Downstream sequence
GTAACTAACTAAAAATCTTAAGTTTAAAAAAAATTAGATACTCAAGTATTAAAGCAATTATCTTTAAAAGATGAAAATGATGCACAATAAATATTGATTT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).