Basic Information
VIS ID
TVIS10006162
Fusion event
HBV-GGTA1P integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
397
Orient
-
Integrated sequence
TCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGATGTGTCTGCGGCGTTTTATC| |ATATTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAA
Host Sequence
Chromosome
chr9
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
124247447/121485169 (Hg38)
End
124247447/121485169 (Hg38)
Orient
-
Location type
Intron
Target gene
GGTA1P
Nearest miRNA
hsa-let-7a-1/Upstream/1240119; hsa-mir-12126/Downstream/634913;
Nearest TSS
ENST00000422679/Upstream/109928; ENST00000489314/Downstream/81888;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/114352, chr9-CpG: 76/Downstream/14358
Upstream sequence
aagaagataaattatacataatataataagagaaaagaaaatgtcatgtTGGTGAAACTTCCATGAAAATTCTCATTTTGCaaaaaaaaaaaaaaaaaaa
Downstream sequence
AGTTCGAAGGGCAGCCAACGGGTCTGCCTGCCAGGGTGTCCTTGGTCCCAGGCCACATGGGCCTACCTTCTCTGGCTCCCTTGCCCTCTGCTCAGTGCTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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