Basic Information
VIS ID
TVIS10006166
Fusion event
HBV-LOC110806263 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1457
Orient
+
Integrated sequence
AATACACCTCCTTCCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGA| |CCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1296717/1296602 (Hg38)
End
1296717/1296602 (Hg38)
Orient
+
Location type
Promoter
Target gene
LOC110806263
Nearest miRNA
hsa-mir-4635/Upstream/233628; hsa-mir-10397/Downstream/12708;
Nearest TSS
ENST00000502646/Upstream/1533; ENST00000605200/Downstream/25227;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/747, chr5-CpG: 18/Downstream/38360
Upstream sequence
TTAATTTCTGGGCAGTCACAAAGCAGATACCCTCTGGAGGATGCAAGGGCTACTTCTTTTTCCTAAGATggcagcttggtgcaattaaaatataggaact
Downstream sequence
TGTGCATGGCGAGGAAACGCCTCCCGGCATTCAATGAAGATCGCTGATACCCAGAAGACACCCCAGTATTATGGGTGCAGTTAGTGTGTCTTTGAAAAGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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