Basic Information
VIS ID
TVIS10006172
Fusion event
HBV-chr13 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1800
Orient
+
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
81842238/81268103 (Hg38)
End
81842238/81268103 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/3569987; hsa-mir-1267/Downstream/6350562;
Nearest TSS
ENST00000623511/Upstream/17665; ENST00000446314/Downstream/2614290;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/612793, chr13-CpG: 18/Downstream/2611426
Nearby gene
RNU6-77P(-2266) ; HIGD1AP2(+4751) ;
Upstream sequence
GAAAAAATGCCACAAAATCATTACAAATGTTTAAGCCCTGTTAACGAAAGATATCTAAGATGACTGCTTCTTTCTGAAAGATCAATTTTAAAAATTAGTA
Downstream sequence
TTTTCACAATTAGTTTGATGATGAGCAATTGTTACACATTCTATATATGATTTTCTGTAATAATGGGCAAGGATGCCCTATCTACATAACTTTCTATCTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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